منابع مشابه
AID Mediates Hypermutation by Deaminating Single Stranded DNA
Activation-induced deaminase (AID) is a protein indispensable for the diversification of immunoglobulin (Ig) genes by somatic hypermutation (SHM), class switch recombination (CSR), and gene conversion. To date, the precise role of AID in these processes has not been determined. Here we demonstrate that purified, tetrameric AID can deaminate cytidine residues in DNA, but not in RNA. Furthermore,...
متن کاملOn the deaminating enzyme of flesh-fly larvae.
THE production of ammonia as their main nitrogenous end-product by flesh-fly larvae is now well known. The mechanism of its production however is still obscure [Messer and McLellan, 1935]. Hobson [1931] for instance was unable to find any evidence of deamination of glycine at PH 6-8 by aqueous extracts of Lucilia sericata larvae. One of us [Brown, 1935] carried out the same experiment using lar...
متن کاملProperties of anthranilate hydroxylase (deaminating), a flavoprotein from Trichosporon cutaneum.
Anthranilate hydroxylase was purified from the yeast Trichosporon cutaneum. This enzyme is a simple flavoprotein which apparently does not require any additional cofactor for the conversion of anthranilate to 2,3-dihydroxybenzoate. Anthranilate hydroxylase has Mr of approximately 95,000, with subunit Mr of 50,000; it contains 2 mol of FAD/mol of enzyme. A number of compounds in addition to anth...
متن کاملZebrafish AID is capable of deaminating methylated deoxycytidines
Activation-induced cytidine deaminase (AID) deaminates deoxycytidine (dC) to deoxyuracil (dU) at immunoglobulin loci in B lymphocytes to mediate secondary antibody diversification. Recently, AID has been proposed to also mediate epigenetic reprogramming by demethylating methylated cytidines (mC) possibly through deamination. AID overexpression in zebrafish embryos was shown to promote genome de...
متن کاملMotility-indole-ornithine medium.
A medium designed for detection of motility, indole, and ornithine decarboxylase production in one tube was devised and evaluated. Results, using 182 strains of Enterobacteriaceae, were the same as obtained with commonly used standard methods, although 11 of 87 positive indole tests were weak with the new medium.
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1974
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)81261-9